Open federal grants for nonprofits
472 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Many federal programs list nonprofits as eligible, and notices often split them into two groups: nonprofits with 501(c)(3) status from the IRS and nonprofits without it. Check which group the notice names. Colleges and universities are usually listed separately even when they are nonprofits.
The list below shows every open opportunity in our database whose official notice lists nonprofits as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · PAR-24-293
Innovative Traffic Safety Enforcement (ITSE) Grant Program
National Highway Traffic Safety Administration · NHTSA-693JJ926R000024-FY26
D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional)
National Institutes of Health · PAS-25-236
Advancement and Innovation in Measurement of Language Development and Predictors (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-112
Advancement and Innovation in Measurement of Language Development and Predictors (R21 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-113
Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)
National Institutes of Health · PAR-24-325
Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)
National Institutes of Health · PAR-24-330
NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
National Institutes of Health · PA-25-080
Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-325
NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)
National Institutes of Health · PAR-24-301
Clinical and Translational Science Award (UM1 Clinical Trial Optional)
National Institutes of Health · PAR-24-272
Research Experiences and/or Mentoring Networks through Research Education to Enhance Clinician-Scientists' Participation in NIDCDs Research (R25 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-020
Leading Edge Acceleration Projects (LEAP) in Health Information Technology
Office of the National Coordinator · NAP-AX-22-001
Home Study and Post-Release Services for Unaccompanied Alien Children​​
Administration for Children and Families - ORR · HHS-2026-ACF-ORR-ZU-0019
BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)
National Institutes of Health · RFA-NS-27-015
Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-248
Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional)
National Institutes of Health · PAR-25-327
NIDCD Research Grants for Translating Basic Research into Clinical Practice (R01 Clinical Trial Optional)
National Institutes of Health · RFA-DC-25-002
NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-135
NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)
National Institutes of Health · PAR-25-313
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.