NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)
National Institutes of Health · Opportunity number PA-25-306
Details summarized from the official notice as of Oct 16, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.
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Key facts
| Opportunity number | PA-25-306 |
|---|---|
| Agency | National Institutes of Health Department of Health and Human Services |
| Assistance listing (ALN, formerly CFDA) | 93.213, 93.393, 93.855, 93.840, 93.273, 93.846, 93.286, 93.399, 93.279, 93.113, 93.172, 93.307, 93.838, 93.233, 93.839, 93.866, 93.143, 93.173, 93.837, 93.395, 93.865, 93.394, 93.879, 93.242, 93.396, 93.361, 93.867 |
| Posted | Dec 18, 2024 |
| Deadline | Jan 7, 2028 |
| Cost sharing or matching required | No |
| Funding type | Grant |
| Category | Health |
| Last updated here | Oct 16, 2026 |
Summary from the notice
Who can apply
The official notice lists these applicant types as eligible:
- Nonprofits with 501(c)(3) status (other than colleges)
- State governments
- Special district governments
- Independent school districts
- Private colleges and universities
- Public and Indian housing authorities
- Small businesses
- Public and state colleges and universities
- Others named in the notice (see the eligibility text)
- City or township governments
- Federally recognized tribal governments
- Nonprofits without 501(c)(3) status (other than colleges)
- For-profit organizations other than small businesses
- County governments
- Other Native American tribal organizations
Who should take a closer look
- Small businesses
- Nonprofits
- Colleges and universities
- State governments
- Local governments
- Tribal governments and organizations
- Larger for-profit companies
Not listed as eligible
- Individuals
Unless the eligibility text in the notice names you, this opportunity is probably not for you.
Eligibility details from the notice
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Registrations you will likely need
Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.
- SAM.gov registration for your organization, which also gives you a Unique Entity ID (UEI). Registration is free.
- A Login.gov account, which Grants.gov uses for sign-in.
- A Grants.gov applicant registration linked to your organization's UEI.
Past awards for this program
Totals for assistance listing 93.213, 93.393, 93.855, 93.840, 93.273, 93.846, 93.286, 93.399, 93.279, 93.113, 93.172, 93.307, 93.838, 93.233, 93.839, 93.866, 93.143, 93.173, 93.837, 93.395, 93.865, 93.394, 93.879, 93.242, 93.396, 93.361, 93.867 from public USASpending.gov data, as of Mar 26, 2026. Past awards do not predict future funding.
| Year | Listing | Awards | Total | Average |
|---|---|---|---|---|
| 2026 | 93.855 | 1 | $1,062,954,652 | $1,062,954,652 |
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