Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and Offices (ICOs) invite applications for the investigator-initiated Program Project (P01). A P01 supports a broadly based, multidisciplinary research program with a specific major scientific objective or theme. The proposed Program Projects are focused on the programmatic interests of one or more of the participating ICOs based on their scientific missions. A program project utilizes research projects with a common central scientific theme, an administrative core, and optional shared resource core(s) to accomplish ICOs' programmatic objectives.
Open for applications
NIH Research Program Projects (Parent P01 Clinical Trial Optional)
National Institutes of Health · Opportunity number PA-27-061
View the official notice on Grants.gov
952 days left
(deadline May 25, 2029)
Details summarized from the official notice as of Oct 16, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.
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Key facts
| Opportunity number | PA-27-061 |
|---|---|
| Agency | National Institutes of Health Department of Health and Human Services |
| Assistance listing (ALN, formerly CFDA) | 93.866, 93.279, 93.837, 93.839, 93.393, 93.838, 93.313, 93.395, 93.855, 93.394, 93.113, 93.233, 93.396, 93.840, 93.879, 93.307, 93.172, 93.273, 93.399 |
| Posted | Oct 14, 2026 |
| Deadline | May 25, 2029 |
| Cost sharing or matching required | No |
| Funding type | Grant |
| Category | Health |
| Last updated here | Oct 16, 2026 |
Summary from the notice
Who can apply
The official notice lists these applicant types as eligible:
- Other Native American tribal organizations
- Nonprofits without 501(c)(3) status (other than colleges)
- Public and Indian housing authorities
- Small businesses
- Special district governments
- Federally recognized tribal governments
- State governments
- Private colleges and universities
- Independent school districts
- Nonprofits with 501(c)(3) status (other than colleges)
- County governments
- Others named in the notice (see the eligibility text)
- City or township governments
- Public and state colleges and universities
- For-profit organizations other than small businesses
Who should take a closer look
- Small businesses
- Nonprofits
- Colleges and universities
- State governments
- Local governments
- Tribal governments and organizations
- Larger for-profit companies
Not listed as eligible
- Individuals
Unless the eligibility text in the notice names you, this opportunity is probably not for you.
Eligibility details from the notice
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Registrations you will likely need
Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.
- SAM.gov registration for your organization, which also gives you a Unique Entity ID (UEI). Registration is free.
- A Login.gov account, which Grants.gov uses for sign-in.
- A Grants.gov applicant registration linked to your organization's UEI.
Past awards for this program
Totals for assistance listing 93.866, 93.279, 93.837, 93.839, 93.393, 93.838, 93.313, 93.395, 93.855, 93.394, 93.113, 93.233, 93.396, 93.840, 93.879, 93.307, 93.172, 93.273, 93.399 from public USASpending.gov data, as of Mar 26, 2026. Past awards do not predict future funding.
| Year | Listing | Awards | Total | Average |
|---|---|---|---|---|
| 2026 | 93.855 | 1 | $1,062,954,652 | $1,062,954,652 |
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