Open for applications

Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)

National Institutes of Health · Opportunity number RFA-DK-27-122

32 days left (deadline Nov 17, 2026)

Details summarized from the official notice as of Oct 16, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.

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Key facts

Opportunity number	RFA-DK-27-122
Agency	National Institutes of Health Department of Health and Human Services
Assistance listing (ALN, formerly CFDA)	93.847
Posted	Oct 15, 2026
Deadline	Nov 17, 2026
Expected number of awards	1
Cost sharing or matching required	No
Funding type	Cooperative agreement
Category	Health
Last updated here	Oct 16, 2026

Summary from the notice

The purpose of this NOFO is to continue the Physiology of the Weight Reduced State (POWERS) clinical trial. The goal of POWERS is to understand the physiological processes underlying individual variability in weight regain following weight loss due to a lifestyle intervention. The continuation of POWERS will allow for the completion of the ongoing clinical trial and to conduct analysis of collected data and biospecimens.

This NOFO invites a single source application from the Data Coordinating Center for the POWERS consortium. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and only meritorious application(s) will be considered for funding.

Who can apply

The official notice lists these applicant types as eligible:

Private colleges and universities
Special district governments
County governments
Public and Indian housing authorities
Small businesses
Federally recognized tribal governments
State governments
Nonprofits without 501(c)(3) status (other than colleges)
Other Native American tribal organizations
Nonprofits with 501(c)(3) status (other than colleges)
City or township governments
Independent school districts
For-profit organizations other than small businesses
Public and state colleges and universities
Others named in the notice (see the eligibility text)

Who should take a closer look

Small businesses
Nonprofits
Colleges and universities
State governments
Local governments
Tribal governments and organizations
Larger for-profit companies

Not listed as eligible

Individuals

Unless the eligibility text in the notice names you, this opportunity is probably not for you.

Eligibility details from the notice

NIDDK requests a Single Source competition for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study at the University of Pittsburgh.

Registrations you will likely need

Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.

SAM.gov registration for your organization, which also gives you a Unique Entity ID (UEI). Registration is free.
A Login.gov account, which Grants.gov uses for sign-in.
A Grants.gov applicant registration linked to your organization's UEI.

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Before you apply

Read the full official notice, including the evaluation criteria.
Confirm your organization type and location are eligible.
Check your SAM.gov registration is active.
Note the exact deadline time and time zone in the notice.