HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · Opportunity number RFA-NS-27-007
Details summarized from the official notice as of Oct 16, 2026. Always confirm eligibility, deadlines and requirements in the official notice before applying.
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Key facts
| Opportunity number | RFA-NS-27-007 |
|---|---|
| Agency | National Institutes of Health Department of Health and Human Services |
| Assistance listing (ALN, formerly CFDA) | 93.395, 93.866, 93.839, 93.867, 93.838, 93.846, 93.840, 93.213, 93.273, 93.853, 93.837, 93.233, 93.279, 93.865 |
| Posted | Jun 16, 2026 |
| Deadline | Feb 20, 2029 |
| Expected number of awards | 3 |
| Estimated total program funding | $11,000,000 |
| Cost sharing or matching required | No |
| Funding type | Cooperative agreement |
| Category | Health |
| Last updated here | Oct 16, 2026 |
Summary from the notice
Who can apply
The official notice lists these applicant types as eligible:
- Private colleges and universities
- Federally recognized tribal governments
- Others named in the notice (see the eligibility text)
- Public and Indian housing authorities
- Nonprofits with 501(c)(3) status (other than colleges)
- Special district governments
- State governments
- County governments
- Nonprofits without 501(c)(3) status (other than colleges)
- Other Native American tribal organizations
- For-profit organizations other than small businesses
- Small businesses
- City or township governments
- Public and state colleges and universities
- Independent school districts
Who should take a closer look
- Small businesses
- Nonprofits
- Colleges and universities
- State governments
- Local governments
- Tribal governments and organizations
- Larger for-profit companies
Not listed as eligible
- Individuals
Unless the eligibility text in the notice names you, this opportunity is probably not for you.
Eligibility details from the notice
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Registrations you will likely need
Most applications submitted through Grants.gov need the following. Registration can take several weeks, so start early. The notice lists the exact requirements.
- SAM.gov registration for your organization, which also gives you a Unique Entity ID (UEI). Registration is free.
- A Login.gov account, which Grants.gov uses for sign-in.
- A Grants.gov applicant registration linked to your organization's UEI.
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