Open federal grants for nonprofits
472 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Many federal programs list nonprofits as eligible, and notices often split them into two groups: nonprofits with 501(c)(3) status from the IRS and nonprofits without it. Check which group the notice names. Colleges and universities are usually listed separately even when they are nonprofits.
The list below shows every open opportunity in our database whose official notice lists nonprofits as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
National Institutes of Health · RFA-OD-25-010
Limited Competition: NIGMS Mature Synchrotron Resources (MSR) for Structural Biology (P30 - Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-068
BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)
National Institutes of Health · RFA-NS-27-001
Development of Candidate Medical Countermeasures (MCMs) and Technologies Against Radiological/Nuclear or Chemical Threats (U01 Clinical Trial Not Allowed)
National Institutes of Health · RFA-AI-27-014
Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 CT Not Allowed)
National Institutes of Health · RFA-HD-27-007
Occupational Safety and Health Education and Research Centers (T42)
Centers for Disease Control and Prevention - ERA · RFA-OH-25-002
Occupational Safety and Health Training Project Grants (T03)
Centers for Disease Control and Prevention - ERA · RFA-OH-25-003
Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)
National Institutes of Health · PAR-27-013
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
National Institutes of Health · PAR-27-012
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
National Institutes of Health · PAR-27-011
Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-362
CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-075
Limited Competition: Small Grant Program for NHLBI K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
National Institutes of Health · RFA-HL-27-004
Community-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · PAR-27-015
The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-26-134
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
National Institutes of Health · PA-26-001
Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-067
Biomedical Technology Optimization and Dissemination Center (BTOD) (RM1 - Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-024
Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI)
National Institutes of Health · PAR-27-032
BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
National Institutes of Health · RFA-NS-28-010
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.