Open federal grants for small businesses
401 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Federal agencies list "small businesses" as eligible on many research, technology and economic development notices. The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs are the best known, but they are not the only ones. Most notices use the size standards of the U.S. Small Business Administration to decide what counts as small.
The list below shows every open opportunity in our database whose official notice lists small businesses as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-175
Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)
National Institutes of Health · PAR-25-291
Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R34 Clinical Trial Required)
National Institutes of Health · PAR-25-288
Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)
National Institutes of Health · PA-25-172
Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)
National Institutes of Health · PAR-25-282
Imaging - Science Track Award for Research Transition (I/START) (R03 Clinical Trial Optional)
National Institutes of Health · PAR-24-297
Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01 Clinical Trial Required)
National Institutes of Health · PAR-25-289
Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-185
Limited Competition: CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed)
National Institutes of Health · PA-25-093
Mechanisms that Impact Cancer Risk after Bariatric Surgery (R21 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-044
Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-243
NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
National Institutes of Health · PA-25-302
Limited Competition: Small Grant Program for NIDDK K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
National Institutes of Health · PAR-25-091
Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Optional)
National Institutes of Health · PAR-25-337
Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)
National Institutes of Health · PAR-25-299
Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)
National Institutes of Health · PAR-25-321
NIDCD Research Dissertation Fellowship for Au.D. Audiologists (F32)
National Institutes of Health · PAR-25-250
NEI Clinical Research Study Planning Grant Program (R34 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-358
Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-346
Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)
National Institutes of Health · PAR-25-283
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.