Open federal grants for small businesses
401 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Federal agencies list "small businesses" as eligible on many research, technology and economic development notices. The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs are the best known, but they are not the only ones. Most notices use the size standards of the U.S. Small Business Administration to decide what counts as small.
The list below shows every open opportunity in our database whose official notice lists small businesses as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-077
Strengthening Ghana Health Service laboratory services, diagnostic networks, and systems for a more effective, efficient, and sustainable response to HIV, TB, and other priority health threats
Centers for Disease Control-GHC · CDC-RFA-JG-26-0178
Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03 Clinical Trial Optional)
National Institutes of Health · PAR-25-155
Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)
National Institutes of Health · RFA-DE-27-001
Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
National Institutes of Health · RFA-CA-27-021
Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
National Institutes of Health · RFA-CA-27-020
PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · RFA-RM-27-012
Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (UG3/UH3, Clinical Trial Optional)
National Institutes of Health · RFA-RM-27-013
The DOE Quantum Genesis Q Competition
Office of Science · DE-FOA-0003657
Nutrition Obesity Research Centers (NORCs) (P30 Clinical Trial Optional)
National Institutes of Health · RFA-DK-27-120
BJA FY 2026 Tribal Justice Training and Technical Assistance Program
Bureau of Justice Assistance · O-BJA-2026-172727
Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults (R34 Clinical Trial Required)
National Institutes of Health · RFA-MH-27-140
Long-term health outcomes of people living with spina bifida
Centers for Disease Control - NCBDDD · CDC-RFA-DD-26-0222
OJJDP FY 2026 Missing and Exploited Children Training and Technical Assistance
Office of Juvenile Justice Delinquency Prevention · O-OJJDP-2026-172744
OJJDP FY 2026 Strengthening Internet Crimes Against Children (ICAC) Technological Investigative Capacity
Office of Juvenile Justice Delinquency Prevention · O-OJJDP-2026-172753
GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
National Institutes of Health · RFA-HG-27-012
GREGoRi Innovation Projects (U01 Clinical Trial Optional)
National Institutes of Health · RFA-HG-27-013
GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
National Institutes of Health · RFA-HG-27-011
BJA FY 2026 National Center for Veterans Justice
Bureau of Justice Assistance · O-BJA-2026-172760
HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
National Institutes of Health · PAR-27-045
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.