Open federal grants for small businesses
401 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Federal agencies list "small businesses" as eligible on many research, technology and economic development notices. The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs are the best known, but they are not the only ones. Most notices use the size standards of the U.S. Small Business Administration to decide what counts as small.
The list below shows every open opportunity in our database whose official notice lists small businesses as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-379
Cancer Research Education Grants Program - Research Experiences (R25 Clinical Trial Not Allowed)
National Institutes of Health · PAR-23-277
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-256
Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R34 Clinical Trial Optional)
National Institutes of Health · PAR-25-159
Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-069
Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-310
Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)
National Institutes of Health · PAR-25-167
National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)
National Institutes of Health · PAR-25-081
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)
National Institutes of Health · PAR-25-025
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)
National Institutes of Health · PAR-25-026
Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed)
National Institutes of Health · PAR-25-070
NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)
National Institutes of Health · PAR-25-032
Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-079
Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-235
Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)
National Institutes of Health · PAR-27-071
Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)
National Institutes of Health · RFA-CA-27-005
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
National Institutes of Health · RFA-NS-25-023
National Bycatch Reduction Engineering Program (BREP) - FY2026/27
DOC NOAA - ERA Production · NOAA-NMFS-FHQ-2027-33398
Medical Scientist Training Program (MSTP) (T32)
National Institutes of Health · PAR-24-128
National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)
National Institutes of Health · PAR-26-138
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.