Open federal grants for small businesses
401 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Federal agencies list "small businesses" as eligible on many research, technology and economic development notices. The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs are the best known, but they are not the only ones. Most notices use the size standards of the U.S. Small Business Administration to decide what counts as small.
The list below shows every open opportunity in our database whose official notice lists small businesses as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
National Institutes of Health · PA-23-317
Advanced Nuclear Energy Licensing Cost-Share Grant Program
Idaho Field Office · DE-FOA-0003339
National Center for Construction Safety and Health Research and Translation (U54)
Centers for Disease Control and Prevention - ERA · RFA-OH-24-001
Accelerating Scale-up and Pre-piloting of Emerging Chemical Technologies (ASPECT)
Golden Field Office · DE-FOA-0003647
John H. Prescott Marine Mammal Rescue Assistance Grant
DOC NOAA - ERA Production · NOAA-NMFS-PRPO-2026-31863
OVC FY 2026 Specialized Human Trafficking Assistance: Task Forces and Legal Services
Office for Victims of Crime · O-OVC-2026-172790
Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)
National Institutes of Health · RFA-OD-27-008
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)
National Institutes of Health · RFA-OD-24-011
MPPEP Phase 3 Invasive Wild-Caught Catfish
Rural Business-Cooperative Service · RD-RBS-26-03-MPPEP
Silicon Carbide Cladding Lead Test Rod Development-Phase 1
Idaho Field Office · DE-FOA-0003577
Cooperative Research Agreements Related to the World Trade Center Health Program (U01)
Centers for Disease Control and Prevention - ERA · RFA-OH-26-001
Exploratory/Developmental Grants Related to the World Trade Center Health Program (R21)
Centers for Disease Control and Prevention - ERA · RFA-OH-26-015
Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)
National Institutes of Health · RFA-HG-27-010
Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
National Institutes of Health · RFA-HG-27-007
Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
National Institutes of Health · RFA-HG-27-009
IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed)
National Institutes of Health · RFA-HG-27-008
SEFSC Bluefin Tuna Research Program
DOC NOAA - ERA Production · NOAA-NMFS-SE-2027-33642
Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-221
Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)
National Institutes of Health · PAR-25-098
Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)
National Institutes of Health · PAR-25-378
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.