Open federal grants for for-profit businesses
395 open opportunities as of Oct 16, 2026.
Independent platform. Not affiliated with or endorsed by any government agency. Data from public federal sources.
Some federal notices are open to for-profit organizations of any size. These are listed separately from small businesses on Grants.gov. A program that lists only "small businesses" is not open to larger companies.
The list below shows every open opportunity in our database whose official notice lists for-profit businesses as an eligible applicant type. Each listing links to a summary page and to the official notice.
Being in an eligible group is only the first check. Read the eligibility section of each notice for location, program focus, cost sharing and other conditions before you start an application.
Open opportunities
NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional)
National Institutes of Health · PAR-24-089
Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)
National Institutes of Health · PAR-25-370
OJJDP FY 2026 Internet Crimes Against Children On-Line Child Protection System (ICACCOPS)
Office of Juvenile Justice Delinquency Prevention · O-OJJDP-2026-172740
NIJ FY 2026 Evaluation of the Effectiveness of the Bureau of Justice Assistance (BJA) Byrne State Crisis Intervention Program (SCIP)
National Institute of Justice · O-NIJ-2026-172798
NIJ FY 2026 Research and Evaluation on Human Trafficking
National Institute of Justice · O-NIJ-2026-172799
NIJ FY 2026 Research and Evaluation on Justice System Responses to Illegal Immigration
National Institute of Justice · O-NIJ-2026-172800
NIJ FY 2026 Crime and Justice Research
National Institute of Justice · O-NIJ-2026-172801
Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)
National Institutes of Health · PAR-25-274
Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)
National Institutes of Health · PAR-25-268
NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)
National Institutes of Health · PAR-25-267
Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)
National Institutes of Health · PAR-25-158
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
National Institutes of Health · PAR-25-096
Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)
National Institutes of Health · RFA-DK-27-122
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)
National Institutes of Health · PAR-25-371
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)
National Institutes of Health · PAR-25-369
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)
National Institutes of Health · PAR-25-052
Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)
National Institutes of Health · PAR-25-226
Easement Restoration and Stewardship
Natural Resources Conservation Service · USDA-NHQ-ACEP-26-NOFO0001456
NIJ FY 2026 Research and Evaluation on School Safety
National Institute of Justice · O-NIJ-2026-172796
Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)
National Institutes of Health · RFA-RM-27-007
Frequently asked questions
Does being listed as eligible mean my organization qualifies?
No. The applicant type is only the first filter. Most notices add more conditions, such as location, program focus, matching funds or prior experience. Read the eligibility section of the official notice before you apply.
Is GovGrantsUSA a government website?
No. GovGrantsUSA is an independent platform operated by VRLY Ventures LLC. It is not affiliated with or endorsed by any government agency. Opportunity details are summarized from public federal sources such as Grants.gov.
Does it cost anything to apply for a federal grant?
Searching for and applying to federal grants on Grants.gov is free. Be wary of anyone who asks for a fee to "release" a grant or guarantees an award.
How current is this information?
Listings are refreshed from public federal data every day, and each page shows when it was last updated. Agencies can change or cancel a notice at any time, so always confirm details in the official notice.
What do I need before I can apply?
Most applicants through Grants.gov need an active SAM.gov registration with a Unique Entity ID (UEI), a Login.gov account and a Grants.gov account linked to their organization. Registration can take several weeks, so start early.